�Data from a Phase II study of an investigational dose designed to block formation of blood line clots demonstrate potential for added auspices against a second heart attack or stroke among patients world Health Organization are already taking state of the art prevention therapy, according to researchers at the Duke Clinical Research Institute.
While the results of the study did non show a statistically important difference in ischemic events among any of the four doses of apixaban evaluated, trends emerged that support farther study, the scientists said.
Apixaban, one of several new anti-platelet agents under exploitation, targets the activity of Factor Xa, an enzyme involved in the process of rake coagulation. Physicians say the need for safer, better anticoagulants is critical because current therapies fall short of therapeutical goals or are difficult to pull off because they increase the risk of bleeding.
"One of the nearly vexing problems in cardiology is identifying the correct combination of drugs that can subdue clot formation but non increase the risk of serious hemorrhage," said study lead John Alexander, M.D., a heart specialist at Duke University Medical Center, world Health Organization presented the findings at the European Society of Cardiology meeting in Munich.
Millions of patients worldwide take anti-clotting drugs on a regular ground. Most are prescribed empirin, clopidogrel (likewise known as Plavix or Iscover) and/or warfarin.
"Warfarin is clearly effective as an anticoagulant, only it is especially hard to pull off properly and safely," Alexander said. "What's driving research in this area is the fact that although aspirin and clopidogrel both offer spunk attack patients important auspices against blood clots, there is still room for improvement. Studies show that a significant number of patients taking aspirin and clopidogrel volition still have some sort of job related to a blood clot. Adding warfarin just increases the likelihood of bleeding complications at a higher rate than anybody is comfortable with."
Alexander, along with Professor Lars Wallentin from the Uppsala Clinical Research Center in Sweden and other colleagues, studied the use of goods and services of apixaban in 1,715 patients from 14 countries end-to-end Europe and North America who had suffered a recent spirit attack. Roughly two-thirds of the patients had undergone angioplasty to clear plugged arteries and 99 pct of them were pickings either empirin or acetylsalicylic acid and clopidogrel.
The study (called APPRAISE) was designed to identify the optimal dose of apixaban. Participants were randomized into one of four doses of apixaban or a placebo. Researchers tracked the incidence of bleeding and recurrent kernel attack, accident, chest pain requiring hospitalization or additional procedures or death from cardiovascular problems for the following six-spot months.
At the end of the field, researchers discovered a non-statistically significant movement suggesting that patients taking apixaban along with their regular treatment had a lower incidence of heart attack, stroke, chest pain or decease from cardiovascular problems than patients pickings a placebo.
But bleeding was an issue, especially among those taking the higher doses of the drug (10 milligrams twice daily or 20 milligrams erst daily). Investigators discontinued those two blazonry of the study because patients were experiencing unsufferable rates of bleeding. Patients in the remaining munition of the study (2.5 milligrams twice daily or 10 milligrams once daily) also experienced more bleeding than those pickings a placebo.
Investigators say that while the results ar not conclusive, they do warrant further study.
"The information show adding 5 or 10 milligrams of apixaban to a regimen of aspirin or aspirin and clopidogrel in patients hoping to keep a s heart attack may offer therapeutic potency," says Alexander. "But this needs to be definitively demonstrated in a statistically significant mode in magnanimous, well-controlled studies."
Apixaban is under development at Bristol-Myers Squibb, the company that sponsored the study.
Alexander and Wallentin have both received inquiry support from Bristol-Myers Squibb.
Source: Michelle Gailiun
Duke University Medical Center
View drug information on PLAVIX; Warfarin Sodium tablets.
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Friday 5 September 2008
Tuesday 26 August 2008
Legend debuting song at Democratic convention
NEW YORK (Billboard) - Soul singer John Legend will debut a new song, "If You're Out There," at Monday night's (August 25) opening session of the Democratic National Convention at Denver's Pepsi Center.
According to a statement, the song is an "anthemic call-to-action and evocation of human potential." It includes such lines as "We're the generation / We can't afford to wait / The next started yesterday and we're already later."
"If You're Out There" features the Agape Choir. It will be available via the Web site my.barackobama.com/johnlegend after the performance just can be purchased beforehand via iTunes.
The song will besides be plant on Legend's next record album, "Evolver," due October 28 via Columbia.
/Billboard
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Saturday 16 August 2008
Download Aerial M
 Artist: Aerial M: mp3 download Genre(s): Rock Discography:  Aerial M Year: 1997 Tracks: 7 Aerial M was the assumed make of multi-instrumentalist David Pajo, a seminal figure in the development of the post-rock aesthetic whose tenures in bands including Slint and Tortoise set the leg for some of the virtually innovational and influential music of belated decades. He first surfaced in 1985 playing guitar in the legendary Louisville, KY, adolescent thrash band Squirrel Bait; following their 1987 detachment, Pajo coupled Slint, a isthmus whose revolutionary implemental sound continues to vibrate throughout the American resistance scene. Slint proved transitory as well, nonetheless, and after their 1991 breakup, he coupled the Palace Brothers, appearing on their early recordings; from thither Pajo relocated to England, where he exhausted over a class poring all over at Norwich Arts College. Upon his return to the U.S. he rejoined the Palace Brothers, additionally playing guitar in the For Carnation and drumming in King Kong. Most important, all the same, was his land land tenure as unrivalled of deuce bassists in Tortoise, which began in 1996 with the watershed Millions Now Living Will Never Die; Pajo curtly left the radical, regular so, to focal point on Aerial M, a solo propose that he debuted with the single "Safeless." "Vol de Nuit," unrivalled half of a stock split unmarried recorded with Monade, followed in previous 1996, trailed a class by and by by Aerial M's self-titled debut LP, issued on the Drag City judge. Post Global Music followed in 1999. Pajo alike recorded and performed under the Papa M false name in the late '90s and early 2000s; performed as a member of Zwan; and secondhand the Pajo byname in the mid-2000s. |
DJ C and Quality Diamond
Thursday 7 August 2008
Hancock
It doesn't happen in many movies, but there's something I like to call the "drop-off point" to describe when a movie turns bad selfsame suddenly. The drop-off full stop of Hancock occurs at the origin of the third move, and I can't
Monday 30 June 2008
Iva Davies goes into Battle
IVA Davies is known to TV audiences now for Battle of the Choirs, but the former Icehouse frontman remains proud of his '80s mega-mullet. Plus, should his band reform?
You've turned down reality TV in the past, but now you're judging on Battle of the Choirs. What made you say yes? This appeals to me because I don't think the people went into their choirs to be TV stars or music stars or dancing stars. They just love doing what they're doing and they'd do it whether there was a TV show there or not. Reality-TV shows love tension between the judges. How's the vibe on Choirs? There have been some tense moments when the judges have been divided. I don't watch any reality TV, I'm a sucker for a good documentary. Your fellow judge Charli from Hi-5 said she was the only one who knew how Pink's Get the Party Started should be sung. True? I'm vaguely aware of that stuff, I have children who are 14 and 12. It's not that I study the charts any more, but a lot of those songs have filtered through. That Mika song (Grace Kelly) was one of my son's favourites for months. Do you listen to much new music? I was a devotee of Pink Floyd and more recently Radiohead, but I've disappeared into that wonderful middle age of life where none of these things become a passion to follow. I think that's the case with many professional musicians, what's recreation to other people is work to us.
Vote Now!
Do you think Icehouse should reform?
Add your vote! Yes No
You've turned down reality TV in the past, but now you're judging on Battle of the Choirs. What made you say yes? This appeals to me because I don't think the people went into their choirs to be TV stars or music stars or dancing stars. They just love doing what they're doing and they'd do it whether there was a TV show there or not. Reality-TV shows love tension between the judges. How's the vibe on Choirs? There have been some tense moments when the judges have been divided. I don't watch any reality TV, I'm a sucker for a good documentary. Your fellow judge Charli from Hi-5 said she was the only one who knew how Pink's Get the Party Started should be sung. True? I'm vaguely aware of that stuff, I have children who are 14 and 12. It's not that I study the charts any more, but a lot of those songs have filtered through. That Mika song (Grace Kelly) was one of my son's favourites for months. Do you listen to much new music? I was a devotee of Pink Floyd and more recently Radiohead, but I've disappeared into that wonderful middle age of life where none of these things become a passion to follow. I think that's the case with many professional musicians, what's recreation to other people is work to us.
Vote Now!
Do you think Icehouse should reform?
Add your vote! Yes No
Tuesday 24 June 2008
Madonna Unveils Robyn As European Tour Support
Swedish pop sensation Robyn will support Madonna on the European leg of here Sticky & Sweet world tour, it's been revealed.
Robyn will tour alongside the singer through August and September has her tour calls in arenas across Europe.
It's not yet clear whether Robyn will support Madonna on her two UK dates, at Cardiff's Millennium Stadium and London's Wembley Arena.
To date, Madonna's tour, in support of her latest album 'Hard Candy', has sold nearly one million tickets.
You can purchase tickets for Madonna's tour here, or by calling our ticket hotline on 0871 230 1098 for more details.
For all the latest concert information, check out our new look Gig Guide.
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Monday 16 June 2008
Claudio Baglioni
Artist: Claudio Baglioni
Genre(s):
Folk
Pop
Ethnic
Other
Rock
Discography:
Buon Viaggio Della Vita Anteprima Tour (cd3)
Year: 2007
Tracks: 13
Buon Viaggio Della Vita Anteprima Tour (cd2)
Year: 2007
Tracks: 10
Buon Viaggio Della Vita Anteprima Tour (cd1)
Year: 2007
Tracks: 12
Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD3
Year: 2007
Tracks: 13
Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD2
Year: 2007
Tracks: 10
Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD1
Year: 2007
Tracks: 12
Quelli Degli Altri Tutti Qui
Year: 2006
Tracks: 30
Tutti Qui: Collezione (CD 3) - 1990-2005
Year: 2005
Tracks: 13
Tutti Qui: Collezione (CD 2) - 1978-1990
Year: 2005
Tracks: 14
Tutti Qui: Collezione (CD 1) - 1967-1976
Year: 2005
Tracks: 17
Crescendo E Cercando (CD 2)
Year: 2005
Tracks: 15
Crescendo E Cercando (CD 1)
Year: 2005
Tracks: 14
Sono Io: L'uomo Della Storia Accanto
Year: 2003
Tracks: 13
Claudio Baglioni
Year: 2003
Tracks: 12
Incanto
Year: 2002
Tracks: 11
Incanto
Year: 2002
Tracks: 12
Incanto (cd3)
Year: 2001
Tracks: 15
Viaggiatore Sulla Coda del Tempo
Year: 2000
Tracks: 12
Oltre
Year: 1999
Tracks: 20
La Vita E' Adesso
Year: 1999
Tracks: 10
E Tu
Year: 1999
Tracks: 10
Anime in Gioco
Year: 1999
Tracks: 18
Gira Che Ti Rigira Amore
Year: 1998
Tracks: 11
Da me a te (Singolo)
Year: 1998
Tracks: 3
Solo
Year: 1997
Tracks: 10
Sabato Pomeriggio
Year: 1997
Tracks: 12
Attori E Spettatori
Year: 1997
Tracks: 26
Ancorassieme
Year: 1992
Tracks: 13
Anteprima tour '91 Baglioni (Singolo)
Year: 1991
Tracks: 4
E Tu Come Stai?
Year: 1990
Tracks: 9
Assolo (cd1)
Year: 1986
Tracks: 12
Ale-OO (cd2)
Year: 1986
Tracks: 12
Un Cantastorie Dei Giorni Nost
Year: 1971
Tracks: 12
Da me a te (Singolo Maxi)
Year:
Tracks: 12
Canzoni inedite (cd2)
Year:
Tracks: 20
Canzoni inedite (cd1)
Year:
Tracks: 17
Assolo (cd2)
Year:
Tracks: 12
Ale-OO (cd1)
Year:
Tracks: 9
Born in Rome in 1951, Claudio Baglioni grew up singing but chased an playacting life history during the tardy '60s. Signed to the Italian division of RCA by the end of the decennary, however, Baglioni moved back to music with his 1970 self-titled debut. He released pentad additional albums for the label until 1977's Solo, moving later on to CBS. His first record album for the new label was 1978's E Tu Come Stai?, and Baglioni continued to record for CBS until 1986, when he temporarily retired. Back in form by 1990, Claudio Baglioni released Oltre for Sony Music, and followed the LP with several albums end-to-end the '90s. He continued his playing life history concurrently, appearance in several films by the famed Italian managing director Franco Zeffirelli.
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