Investigational Factor Xa Compound: Data Presented At European Heart Meeting

�Data from a Phase II study of an investigational dose designed to block formation of blood line clots demonstrate potential for added auspices against a second heart attack or stroke among patients world Health Organization are already taking state of the art prevention therapy, according to researchers at the Duke Clinical Research Institute.



While the results of the study did non show a statistically important difference in ischemic events among any of the four doses of apixaban evaluated, trends emerged that support farther study, the scientists said.



Apixaban, one of several new anti-platelet agents under exploitation, targets the activity of Factor Xa, an enzyme involved in the process of rake coagulation. Physicians say the need for safer, better anticoagulants is critical because current therapies fall short of therapeutical goals or are difficult to pull off because they increase the risk of bleeding.



"One of the nearly vexing problems in cardiology is identifying the correct combination of drugs that can subdue clot formation but non increase the risk of serious hemorrhage," said study lead John Alexander, M.D., a heart specialist at Duke University Medical Center, world Health Organization presented the findings at the European Society of Cardiology meeting in Munich.



Millions of patients worldwide take anti-clotting drugs on a regular ground. Most are prescribed empirin, clopidogrel (likewise known as Plavix or Iscover) and/or warfarin.



"Warfarin is clearly effective as an anticoagulant, only it is especially hard to pull off properly and safely," Alexander said. "What's driving research in this area is the fact that although aspirin and clopidogrel both offer spunk attack patients important auspices against blood clots, there is still room for improvement. Studies show that a significant number of patients taking aspirin and clopidogrel volition still have some sort of job related to a blood clot. Adding warfarin just increases the likelihood of bleeding complications at a higher rate than anybody is comfortable with."



Alexander, along with Professor Lars Wallentin from the Uppsala Clinical Research Center in Sweden and other colleagues, studied the use of goods and services of apixaban in 1,715 patients from 14 countries end-to-end Europe and North America who had suffered a recent spirit attack. Roughly two-thirds of the patients had undergone angioplasty to clear plugged arteries and 99 pct of them were pickings either empirin or acetylsalicylic acid and clopidogrel.



The study (called APPRAISE) was designed to identify the optimal dose of apixaban. Participants were randomized into one of four doses of apixaban or a placebo. Researchers tracked the incidence of bleeding and recurrent kernel attack, accident, chest pain requiring hospitalization or additional procedures or death from cardiovascular problems for the following six-spot months.



At the end of the field, researchers discovered a non-statistically significant movement suggesting that patients taking apixaban along with their regular treatment had a lower incidence of heart attack, stroke, chest pain or decease from cardiovascular problems than patients pickings a placebo.



But bleeding was an issue, especially among those taking the higher doses of the drug (10 milligrams twice daily or 20 milligrams erst daily). Investigators discontinued those two blazonry of the study because patients were experiencing unsufferable rates of bleeding. Patients in the remaining munition of the study (2.5 milligrams twice daily or 10 milligrams once daily) also experienced more bleeding than those pickings a placebo.



Investigators say that while the results ar not conclusive, they do warrant further study.



"The information show adding 5 or 10 milligrams of apixaban to a regimen of aspirin or aspirin and clopidogrel in patients hoping to keep a s heart attack may offer therapeutic potency," says Alexander. "But this needs to be definitively demonstrated in a statistically significant mode in magnanimous, well-controlled studies."





Apixaban is under development at Bristol-Myers Squibb, the company that sponsored the study.



Alexander and Wallentin have both received inquiry support from Bristol-Myers Squibb.



Source: Michelle Gailiun

Duke University Medical Center




View drug information on PLAVIX; Warfarin Sodium tablets.



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Legend debuting song at Democratic convention

NEW YORK (Billboard) - Soul singer John Legend will debut a new song, "If You're Out There," at Monday night's (August 25) opening session of the Democratic National Convention at Denver's Pepsi Center.

According to a statement, the song is an "anthemic call-to-action and evocation of human potential." It includes such lines as "We're the generation / We can't afford to wait / The next started yesterday and we're already later."

"If You're Out There" features the Agape Choir. It will be available via the Web site my.barackobama.com/johnlegend after the performance just can be purchased beforehand via iTunes.

The song will besides be plant on Legend's next record album, "Evolver," due October 28 via Columbia.

/Billboard

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• Download To Die For
• Download Soul Asylum
• Download Anathema
• The House Bunny
• Tarwater | Download mp3

Download Aerial M

Artist: Aerial M: mp3 download    Genre(s):  Rock     Discography:      Aerial M    Year: 1997    Tracks: 7 Aerial M was the assumed make of multi-instrumentalist David Pajo, a seminal figure in the development of the post-rock aesthetic whose tenures in bands including Slint and Tortoise set the leg for some of the virtually innovational and influential music of belated decades. He first surfaced in 1985 playing guitar in the legendary Louisville, KY, adolescent thrash band Squirrel Bait; following their 1987 detachment, Pajo coupled Slint, a isthmus whose revolutionary implemental sound continues to vibrate throughout the American resistance scene. Slint proved transitory as well, nonetheless, and after their 1991 breakup, he coupled the Palace Brothers, appearing on their early recordings; from thither Pajo relocated to England, where he exhausted over a class poring all over at Norwich Arts College. Upon his return to the U.S. he rejoined the Palace Brothers, additionally playing guitar in the For Carnation and drumming in King Kong. Most important, all the same, was his land land tenure as unrivalled of deuce bassists in Tortoise, which began in 1996 with the watershed Millions Now Living Will Never Die; Pajo curtly left the radical, regular so, to focal point on Aerial M, a solo propose that he debuted with the single "Safeless." "Vol de Nuit," unrivalled half of a stock split unmarried recorded with Monade, followed in previous 1996, trailed a class by and by by Aerial M's self-titled debut LP, issued on the Drag City judge. Post Global Music followed in 1999. Pajo alike recorded and performed under the Papa M false name in the late '90s and early 2000s; performed as a member of Zwan; and secondhand the Pajo byname in the mid-2000s.

DJ C and Quality Diamond

Hancock

It doesn't happen in many movies, but there's something I like to call the "drop-off point" to describe when a movie turns bad selfsame suddenly. The drop-off full stop of Hancock occurs at the origin of the third move, and I can't

Iva Davies goes into Battle

IVA Davies is known to TV audiences now for Battle of the Choirs, but the former Icehouse frontman remains proud of his '80s mega-mullet. Plus, should his band reform?
You've turned down reality TV in the past, but now you're judging on Battle of the Choirs. What made you say yes? This appeals to me because I don't think the people went into their choirs to be TV stars or music stars or dancing stars. They just love doing what they're doing and they'd do it whether there was a TV show there or not. Reality-TV shows love tension between the judges. How's the vibe on Choirs? There have been some tense moments when the judges have been divided. I don't watch any reality TV, I'm a sucker for a good documentary. Your fellow judge Charli from Hi-5 said she was the only one who knew how Pink's Get the Party Started should be sung. True? I'm vaguely aware of that stuff, I have children who are 14 and 12. It's not that I study the charts any more, but a lot of those songs have filtered through. That Mika song (Grace Kelly) was one of my son's favourites for months. Do you listen to much new music? I was a devotee of Pink Floyd and more recently Radiohead, but I've disappeared into that wonderful middle age of life where none of these things become a passion to follow. I think that's the case with many professional musicians, what's recreation to other people is work to us.

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Madonna Unveils Robyn As European Tour Support

Swedish pop sensation Robyn will support Madonna on the European leg of here Sticky & Sweet world tour, it's been revealed.



Robyn will tour alongside the singer through August and September has her tour calls in arenas across Europe.



It's not yet clear whether Robyn will support Madonna on  her two UK dates, at Cardiff's Millennium Stadium and London's Wembley Arena.



To date, Madonna's tour, in support of her latest album 'Hard Candy', has sold nearly one million tickets.



You can purchase tickets for Madonna's tour here, or by calling our ticket hotline on 0871 230 1098 for more details.



For all the latest concert information, check out our new look Gig Guide.

Buy Madonna tickets


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Claudio Baglioni

   
Artist: Claudio Baglioni

   Genre(s): 
Folk
   Pop
   Ethnic
   Other
   Rock
   

---

Discography:


   
 Buon Viaggio Della Vita Anteprima Tour (cd3)

   Year: 2007   
Tracks: 13


   
 Buon Viaggio Della Vita Anteprima Tour (cd2)

   Year: 2007   
Tracks: 10


   
 Buon Viaggio Della Vita Anteprima Tour (cd1)

   Year: 2007   
Tracks: 12


   
 Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD3

   Year: 2007   
Tracks: 13


   
 Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD2

   Year: 2007   
Tracks: 10


   
 Buon Viaggio Della Vita - Anteprima Tour Tutti Qui CD1

   Year: 2007   
Tracks: 12


   
 Quelli Degli Altri Tutti Qui

   Year: 2006   
Tracks: 30


   
 Tutti Qui: Collezione (CD 3) - 1990-2005

   Year: 2005   
Tracks: 13


   
 Tutti Qui: Collezione (CD 2) - 1978-1990

   Year: 2005   
Tracks: 14


   
 Tutti Qui: Collezione (CD 1) - 1967-1976

   Year: 2005   
Tracks: 17


   
 Crescendo E Cercando (CD 2)

   Year: 2005   
Tracks: 15


   
 Crescendo E Cercando (CD 1)

   Year: 2005   
Tracks: 14


   
 Sono Io: L'uomo Della Storia Accanto

   Year: 2003   
Tracks: 13


   
 Claudio Baglioni

   Year: 2003   
Tracks: 12


   
 Incanto

   Year: 2002   
Tracks: 11


   
 Incanto

   Year: 2002   
Tracks: 12


   
 Incanto (cd3)

   Year: 2001   
Tracks: 15


   
 Viaggiatore Sulla Coda del Tempo

   Year: 2000   
Tracks: 12


   
 Oltre

   Year: 1999   
Tracks: 20


   
 La Vita E' Adesso

   Year: 1999   
Tracks: 10


   
 E Tu

   Year: 1999   
Tracks: 10


   
 Anime in Gioco

   Year: 1999   
Tracks: 18


   
 Gira Che Ti Rigira Amore

   Year: 1998   
Tracks: 11


   
 Da me a te (Singolo)

   Year: 1998   
Tracks: 3


   
 Solo

   Year: 1997   
Tracks: 10


   
 Sabato Pomeriggio

   Year: 1997   
Tracks: 12


   
 Attori E Spettatori

   Year: 1997   
Tracks: 26


   
 Ancorassieme

   Year: 1992   
Tracks: 13


   
 Anteprima tour '91 Baglioni (Singolo)

   Year: 1991   
Tracks: 4


   
 E Tu Come Stai?

   Year: 1990   
Tracks: 9


   
 Assolo (cd1)

   Year: 1986   
Tracks: 12


   
 Ale-OO (cd2)

   Year: 1986   
Tracks: 12


   
 Un Cantastorie Dei Giorni Nost

   Year: 1971   
Tracks: 12


   
 Da me a te (Singolo Maxi)

   Year:    
Tracks: 12


   
 Canzoni inedite (cd2)

   Year:    
Tracks: 20


   
 Canzoni inedite (cd1)

   Year:    
Tracks: 17


   
 Assolo (cd2)

   Year:    
Tracks: 12


   
 Ale-OO (cd1)

   Year:    
Tracks: 9

---

Born in Rome in 1951, Claudio Baglioni grew up singing but chased an playacting life history during the tardy '60s. Signed to the Italian division of RCA by the end of the decennary, however, Baglioni moved back to music with his 1970 self-titled debut. He released pentad additional albums for the label until 1977's Solo, moving later on to CBS. His first record album for the new label was 1978's E Tu Come Stai?, and Baglioni continued to record for CBS until 1986, when he temporarily retired. Back in form by 1990, Claudio Baglioni released Oltre for Sony Music, and followed the LP with several albums end-to-end the '90s. He continued his playing life history concurrently, appearance in several films by the famed Italian managing director Franco Zeffirelli.

Cannes Film Festival - Movie Reviews Changeling

Clint Eastwood's Changeling
has drawn some of the strongest early reviews yet at the Cannes Film Festival. (Critics
were unsure what the actual title was. The festival said on Tuesday that it had received
a written notice from the studio that the title had been changed to The Exchange
, aligning it with the French title, L'Échange. But at a news conference
Eastwood implied that he had not agreed to a such a change, and the daily festival
program, after revising the title on Tuesday changed it back to The Changeling today.)
Geoffrey MacNab in the London Independent called the film a "magisterial piece
of work." While predicting that the movie won't become a big box-office success for
Eastwood, he concluded that "in its unfussy craftsmanship and emotional punch, it shows
him still at the peak of his powers." Writing for the British trade publication Screen
Daily, Mike Goodridge predicted that the movie will "go all the way from the
Palais to the Academy Awards." Several critics attending the screening came away forecasting
an Oscar nomination not only for Eastwood but also for the film's star, Angelina
Jolie. "She is the entire, anxious point of Eastwood's film," wrote James Christopher
in the London Times, "and absolutely terrific." Todd McCarthy in Daily Variety
called her performance "top notch." And Kurt Honeycutt wrote in the Hollywood
Reporter, "Jolie puts on a powerful emotional display."

21/05/2008

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Jamie Lynn to be mom of a girl

The Spears family may have another star to boast of in about 10 years. Spears family Britney's baby sister is pregnant with a girl rumours have surfaced. The Zoey 101 actress was being boasted of by her mom who said that she was expecting a little girl. The star is due on June 29th. She is already seven months pregnant. Meanwhile preparation are abuzz to welcome whoever it is in the family. The teen star was house hunting with fiance Casey Aldridge looking for a home in their native Louisiana to raise the child a 'normal kid'. The announcement may be good for the Spears clan a large blemish on whom is Britney Spears. The loss that her erratic behaviour is said to have cost her a huge 61 million dollars in the nbon promotion of her album Blackout by touring, her rehab escapades and all the other bizarre events that have been followed another bizarre incident.

Milt Buckner

   
Artist: Milt Buckner

   Genre(s): 
Blues
   

---

Discography:


   
 Collection (Boogie Woogie)

   Year:    
Tracks: 1

---

Milt Buckner had a duple career. As a pianist, he largely invented the "locked men" style (parallel chords) that was adoptive by many other players including George III Shearing and Academy Award Peterson. And as an organist, he was i of the top pre-Jimmy Ian Smith stylists, helping to popularise the cat's-paw.


The younger chum of alto saxophonist Ted Buckner (earth Health Governance played with Jimmie Lunceford), Milt Buckner grew up in Motown and gigged topically, in addition to transcription for McKinney's Cotton plant Pickers in 1934. He came to celebrity as pianist and arranger with Lionel Lionel Hampton (1941-1948, 1950-1952, and like a shot and then in by and by years) where he was a crowd pleaser. During 1948-1950, Buckner light-emitting semiconductor diode his have bands and, afterwards 1952, he broadly speech production played pipe organ with trios or quartets. In subsequently long time, he sometimes teamed up with Illinois Jacquet or Jo John Paul Jones. Buckner recorded many dates as a leader, peculiarly for Shirley Temple Black & Amobarbital sodium in the seventies.

New Wuthering Heights in the works

New Wuthering Heights in the works

A new moving-picture show reading of Emily Bronte's 'Wuthering Heights' is to be made.
Variety show reports that 'Love is the Devil' film director Lavatory Maybury will helm the movie.
Maybury is presently finish the fresh drama 'The Bound of Love', which stars Keira Knightley, Sienna Henry Valentine Miller and Irish Gaelic role player Cillian White potato.
Molding has begun for 'Wuthering Heights' and the film is due to begin shooting in the fall.

Evan Dando set for rare intimate UK gig

Evan Dando set for rare intimate UK gig

Evan Dando is set to do the whole of The Lemonheads' classic 1992 album 'It's A Shame Some Ray' in full at an suggest UK gig.

The singer volition play The Cluny in Newcastle-upon-Tyne on May 26.

Tickets are available from Beatdown Records in Newcastle's Vine Lane.

In the first place this month 'It's A Shame Almost Ray' was named Classic Album at the inaugural address NME Awards Army.

Rivers Cuomo - Alone: The Home Recordings of Rivers Cuomo

Rivers Cuomo - Alone: The Home Recordings of Rivers Cuomo

In an eRA where the majority of rock candy stars aren't very interesting, there's often to like about the kookiness of Rivers Cuomo.
Having apparently lived in a wardrobe for weeks on end; sold all his possessions browning automatic rifle a guitar to buy a one-room basement flat; left hand tilt 'n' hustle for a level at Harvard University, and gone on sex binges followed by age of abstinence, Weezer's frontman has, justifiedly or wrongly, garnered a report as rock's weirdie.
Something of a hesitant rock star, it is peculiar then that Cuomo has straightaway decided to raid his nigh 20-year appeal of demo recordings and allowed us in.
Recorded between 1992 and 2007, the 18-track accumulation is to a greater extent a peculiarity for Weezer fans than anything else with the quality of a lot of the recordings questionable. With many, it's soft to see why they haven't made it on to Weezer albums, patch others point to Cuomo's sometime desire to experiment outside of Weezer's structured sound and prickteaser with other genres.
'This Is The Way', single of the more recent demos, was seemingly considered as a lead 1 for the band's forthcoming album and is ace of the to a greater extent experimental sounding tracks here in that it has a sleazy hip-hop palpate to it. You can characterisation bling bling, gold and inkiness rappers with Cuomo looking odd and out of place somewhere in-between.
Cuomo's geek-eyed sensitivity flows to the magnetic core on tracks like 'Wanda (You're My Only Passion)', which was intended to soundtrack the motion-picture show 'Angus', and the excellent 'Chess' and 'Longtime Sunshine'.
'Blast Off', however, is the standout runway and i which would feel at nursing home on any Weezer record album.
Recorded as part of the band's second album roger Sessions, Cuomo had intended to release a "space-voyage rock opera" entitled 'Songs from the Blackhole', and so many of the songs here were intended for that influence.
Hardcore Weezer fans will be companion with these tracks, along with much of 'Alone'. Many of the songs get antecedently cropped up online, along with a legion of other to a lesser extent focussed demos.
I of the best things around the record, notwithstanding, is Cuomo's arm notes. The songster openly describes how for each one track came around and what was leaving on in his life sentence at the time.
It's an engaging companion to the 18-tracks and, thankfully, 'Alone' doesn't look like organism the only road into the workings of Cuomo's creative judgement. He's presently looking on a publishing house for his memoirs - now that should prove fascinating.
Steve